2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W754546
    2-Formyl sunitinib
    2-Formyl sunitinib (1-CHO) is a metabolite of tyrosine kinase inhibitor Sunitinib (HY-10255A). 2-Formyl sunitinib can be used for the research of cancer.
    2-Formyl sunitinib
  • HY-W728123
    Alpelisib carboxylic acid
    Alpelisib carboxylic acid is the major metabolite of Alpelisib (HY-15244).
    Alpelisib carboxylic acid
  • HY-N3103R
    p-Coumaric Acid Ethyl Ester (Standard)
    Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
    p-Coumaric Acid Ethyl Ester (Standard)
  • HY-178962
    Antitumor agent-207
    Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC50 = 1.79 μM), TE-10 (IC50 = 1.95 μM), KYSE-30 IC50 = 5.99 μM), KYSE-520 (IC50 = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer.
    Antitumor agent-207
  • HY-158547
    Etherolenic acid
    Etherolenic acid, a divinyl ether oxylipin, is a metabolite of Linolenic acid.
    Etherolenic acid
  • HY-182727
    MDL 72392
    MDL 72392 is a selective irreversible monoamine oxidase A (MAO-A) inhibitor. MDL 72392 inhibits MAO-A. MDL 72392 is formed by decarboxylation of the bioprecursor amino acid MDL 72394 via aromatic L-amino acid decarboxylase. MDL 72392 can be used in melatonin biosynthesis research.
    MDL 72392
  • HY-G0014S
    Quetiapine Sulfoxide-d8
    Quetiapine Sulfoxide-d8 is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine Sulfoxide-d<sub>8</sub>
  • HY-119696S1
    MTIC-13C
    MTIC-13C is the 13C-labeled MTIC (HY-119696). MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity
    MTIC-<sup>13</sup>C
  • HY-178088
    L-731120
    L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC50 = 260 nM). L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia.
    L-731120
  • HY-128459
    N-Demethylerythromycin A
    N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic.
    N-Demethylerythromycin A
  • HY-137152
    8-Aminoclonazolam
    8-Aminoclonazolam is a benzodiazepine and clonazolam metabolite.
    8-Aminoclonazolam
  • HY-116627
    (R)-6-Hydroxybuspirone
    (R)-6-Hydroxybuspirone is a metabolite of the anxiolytic agent Buspirone (HY-B1115A). (R)-6-Hydroxybuspirone itself also has anxiolytic activity.
    (R)-6-Hydroxybuspirone
  • HY-G0003A
    Milsaperidone
    Milsaperidone ((S)-Hydroxy Iloperidone) is an active metabolite of the antipsychotic agent Iloperidone (HY-17410). Milsaperidone is a dopamine D2 and 5-HT2A receptor antagonist. Milsaperidone rapidly converts to Iloperidone when taken orally. Milsaperidone can be used in the research of mental illnesses such as depression.
    Milsaperidone
  • HY-U00199S
    N-Desmethyl zopiclone-d8
    N-Desmethyl zopiclone-d8 is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
    N-Desmethyl zopiclone-d<sub>8</sub>
  • HY-W776973
    Glycidamide-13C3
    Glycidamide-13C3 (Oxiranecarboxamide-13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects.
    Glycidamide-<sup>13</sup>C<sub>3</sub>
  • HY-W750708
    Idoxanthin
    Idoxanthin is a metabolite of Astaxanthin (HY-B2163). Idoxanthin is involved in the metabolic pathway of Carotenoids, and its formation and accumulation reflect the metabolic capacity and metabolic pathways of different fish species.
    Idoxanthin
  • HY-134242
    6-T-5'-GMP disodium
    6-T-5'-GMP disodium is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, azathioprine (HY-B0256).
    6-T-5'-GMP disodium
  • HY-164611
    ZM 213689
    ZM 213689 is a major metabolite of Meropenem (HY-13678), and it can be detected in both plasma and urine.
    ZM 213689
  • HY-144957S
    Abiraterone N-oxide-d4
    Abiraterone N-oxide-d4 is the deuterium labeled Abiraterone N-oxide (HY-148376). Abiraterone N-oxide is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible?CYP17A1 inhibitor?with antiandrogen activity.
    Abiraterone N-oxide-d<sub>4</sub>
  • HY-B1069R
    Molsidomine (Standard)
    Molsidomine (Standard) (SIN-10 (Standard)) is the analytical standard of Molsidomine (HY-B1069). This product is intended for research and analytical applications. Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications.
    Molsidomine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity